Molecular Structure, Vibrational and Antibacterial Activity Studies on Mono 4-Sulfamoylanilinium Citrate Crystal
25 Apr, 2022
10 Aug, 2022
01 Oct, 2022
Background and Objective: Sulfa drugs were mostly prescribed as chemotherapeutic agents for the treatment of infectious diseases. The structural modifications were preferred due to reducing the toxicity effect of the drug molecule. Many studies had been encountered on the synthesis of sulfanilamide derivative complex crystal. In this manner, the present work was carried out to grow the mono 4-sulfamoylanilinium citrate (M4-SAC) complex crystal in an organic-inorganic hybrid. Materials and Methods: Sulfanilamide, citric acid, distilled water and ethanol was used in this crystallization process. The single crystals were harvested from the slow evaporation method at room temperature. Results: The 3D molecular structure was computed using Chem3D software. The obtained crystal was analyzed by powder X-ray diffraction, FT-IR, FT-Raman, Optical, SEM with EDX and antimicrobial activity studies. Conclusion: The crystal structure of the M4-SAC compound had a sulfamoylanilium cation and a citrate anion which were interlinked through the N—H...O hydrogen bond. To elucidate the crystalline nature of the material, a powder XRD study can be used. The various functional groups present in the title crystal were assigned using IR and Raman spectroscopic techniques. The optical band gap was determined as 3.9 eV. The SEM with EDX study confirms the formation of the M4-SAC complex crystal. The antimicrobial activity study reveals that the complex crystal enhanced the inhibition zone against Bacillus subtilis and Acinetobacter baumannii bacteria.
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